Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Flegel C(1), Vogel F(1,)(2), Hofreuter A(1), Wojcik S(1), Schoeder C(3), Kieć-Kononowicz K(4), Brockmeyer NH(5,)(6), Müller CE(3), Becker C(7), Altmüller J(7), Hatt H(1), Gisselmann G(1).

INTRODUCTION: Modulation of the CB2 receptor is an interesting approach for pain and inflammation, arthritis, addictions, neuroprotection, and cancer, among other possible therapeutic applications, and is devoid of central side effects.

AGOSTO 2016 - BACKGROUND AND OBJECTIVES: Although new psychoactive substances (NPS) continue to emerge at a rapid rate, US national surveys only measure the use of non-specific categories of NPS and are not designed to access high-risk populations.